sfzombie13 t1_ithfzix wrote
Reply to comment by triffid_boy in Research shows stem cell-derived neurons from combat veterans with and without post-traumatic stress disorder (PTSD) provide insights into how genetics can make someone more susceptible to developing PTSD following trauma exposure by Wagamaga
no, i'm suggesting they rephrase the statement, as 39 is not a large number of people for ANY type of study. i would think thousands would suffice for large, not under 50. semantics mostly, but sure, now that you've mentioned it, it needs to be at least in the hundreds to be accurate i'd think, or else they'd be getting at most three people per group selected for. it's hard to get a very diverse group of anything with only 39 members, especially with the differences in people.
there could be more than 10 different geographical influences across the us, and then throw in ethnic groups, gender, and economic class and you've got like one representative from each. not much of a diverse study at all that way.
triffid_boy t1_ithkgw0 wrote
The studies are not on the people, they're trying to identify genetic targets and generate models to use in vitro. It's completely valid.
sfzombie13 t1_itiegsp wrote
no, but they're using people. that's where the genes come from, and with only 39 of them, and all of them vets with ptsd, how do they know they have enough of a diverse sample to make any meaningful connections that can't be explained by chance?
triffid_boy t1_itih0qo wrote
A reasonable case is given through the other studies in the paper to be honest, e.g demonstrating that they have similar transcriptomic signatures to post mortem brains with PTSD.
Viewing a single comment thread. View all comments