I brought dissociatives up as I thought that was where you were talking to bringing up NMDA receptors.

You are right that all of these things affect more than just the the primary target, that being the reuptake, release, agonism/antagonism of the primary receptor target. Any drug affecting a monoamine neurotransmitter is going to have downstream effects on others, and many receptors have specific action on regulating feedback loops on the other neuorotransmitters.

I was really only speaking to the direct effect for brevity if nothing else. I'm also aware that the down-regulation of the serotonergic system over time is considered a likely part of the antidepressant mechanism of SSRIs. In general, I agree with pretty much everything you said.

> "Also as of like, last month, “we don’t know how psychedelics induce this neuroplastic change” is an outdated statement"

I hadn't seen that. Mind linking the paper? Sounds like an interesting read.