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It is referenced in this article as Toludesvenlafaxine. This was just published. It has been available in China since last November and is expected to be available in the U.S. in 2024. It will be the first full SNDRI available on the market.

I thought there was a big meta study recently disproving the seretonin chemical connection to depression?

That was something that was know for decades. They don't know exactly what role serotonin plays in depression. Within the last few months they just published a paper about how they have been able to for the first time have been able to measure serotonin in the human brain. It even showed that people who were depressed showed lower levels of serotonin. This will bring new research to find exactly the role of serotonin plays in depression and hopefully develop more effective medications. That study you referred to also left out the fact there are other neurotransmitters involved including norepinephrine and dopamine. Ruoxinlin works on all 3 neurotransmitters. The only medication to do this so far has been nefazodone (weak SNDRI due to low effect on dopamine).

Nefazodone ..

Haven’t heard that drug name in years !

https://en.m.wikipedia.org/wiki/Nefazodone

Withdrawn due to toxicity

It has never been withdrawn from the United States. I have been taking it for 23 years. That liver problem was way over blown.

This is a good example of how causality is not always straightforward.

Serotonin reuptake inhibitors do work and work better the better in people with more severe depression symptoms.

However they generally can only be expected to work after around 2-4 weeks where as the serotonin increase is on day 1.

The mechanism isn't exactly "more serotonin = more happy" but that's a bit complex for most people.

Citation? Because if you're referencing that amphetamine challenge paper you are way off the mark. We have definitely had methods to image extracellular serotonin via radio-labelled serotonin receptor ligands for decades.

It says in here it is a new method to measure the release on the brain. https://scitechdaily.com/serotonin-deficiency-directly-linked-with-depression-in-groundbreaking-study/

I think a new working hypothesis may be that these drugs end up up regulating the synthesis of BDNF over a longer period of time, so while it does increase serotonin, that may be unrelated to why the drugs actually end up helping people in the sense it’s not the serotonin that is decreasing the depression, but something downstream