chrisdh79 OP t1_jeensqv wrote
From the article: Now, a promising new drug has been developed that targets the nerve activity that causes both heart failure and sleep apnea. Researchers from the University of Auckland in New Zealand tested the drug, known as AF-130, on rats with chronic heart failure and sleep apnea. They found that AF-130 acted as an effective P2X3 receptor antagonist, normalizing the body’s respiratory response to hypoxia and substantially improving the amount of blood pumped by the heart (cardiac output). Breathing disturbances were eliminated.
“This drug does offer benefit for heart failure, but it’s two for the price of one, in that it’s also relieving the apnea for which there is currently no drug, only CPAP, which is poorly tolerated,” said Julian Paton, corresponding author of the study.
AF-130 was also found to reduce systemic inflammation, reduce the weight of the heart, and prevent fluid from gathering in the lungs (pulmonary edema), a common side effect of heart failure. It’s the first drug to control the brain-to-heart nervous activity that drives heart failure and associated sleep apnea.
The study’s findings support the notion that P2X3 receptors in the carotid arteries play a key role in the pathological mechanisms underlying cardiovascular and respiratory diseases.
WoolyLawnsChi t1_jeer3jh wrote
CPAP is poorly tolerated?
Not by me
historycat95 t1_jeeuvw3 wrote
Very much by me.
Tried 5 different masks over 15 months. Never a good night's sleep.
Absolutely horrible.
IcallBSonthat t1_jefcdqz wrote
Have you tried the Philips Dreamwear? No hard plastic parts. If that doesn't work, try adjusting the pressure to lower.
Cabshank t1_jefmr8o wrote
This, dreamwear is the best
sheikrock t1_jegnzas wrote
Try one of the mouth guards. I couldn’t deal with the CPAP, but the mouth guard works great. You do need to have a decent teeth though.
wotmate t1_jeewz69 wrote
It is by me. I've got 100% compliance over the last five months, with an average AHI of 3 using my cpap, and every single day I wake up feeling horrible, and still get drowsy during the day.
Hellspawn54 t1_jegq5hq wrote
I've got (almost) 100% compliance for the past 23 years, and like you have AHI around 3. Also wake up feeling crap, but I know how much worse I would feel without CPAP. It feels like punishment but it's also a lifesaver.
IcallBSonthat t1_jefcm3i wrote
3 AHI isn't that bad. Anything under 5 is actually quite good. Have you tinkered with the settings?
ImportantRope t1_jeey3w4 wrote
In general, it has a low tolerance. It's kind of like sleep deprivation torture for me so it's a lose lose.
Kevine04 t1_jegp7oq wrote
I have used my machine every day for 12 years, I tolerate it, I would do anything to be rid of it.
ShotTreacle8209 t1_jefzyqo wrote
It is hated by me, a spouse. Whereas we used to spoon, now we can’t without cold air blowing down my back.
[deleted] t1_jeewe2c wrote
[removed]
typesett t1_jefg08e wrote
I find breathing exercises help me fall asleep! No Cpap for me tho
Tony2Punch t1_jegnkuu wrote
Literally just have not been able to keep a mask on for a full night after trying a lot
natanaru t1_jeeulwm wrote
Only for me on bad allergy/cold days.
BranWafr t1_jeew5ib wrote
My preferred mask is a nasal pillow, which I use 95% of the time. But when I get allergies or colds that cause stuffy noses, I use the full face mask that covers my mouth, too.
But, if I could take a medication to handle my apnea, I'd be down for that.
murderedbyaname t1_jegp8vf wrote
Statistically as reported by doctors.
CCriscal t1_jegp7nf wrote
Well, CPAP is hardly tolerated by spouses sometimes and it can also make you nervous.
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