There is no difference, as a thyroid cancer survivor I have many times experienced that our feelings and behavior are very much the result of our physical state. I have gone through a severe thyroid hormone overdose recently due to age-related slowing down of metabolism and it caused such strong panic attacks and disturbing thoughts that I was seriously contemplating suicuide. It took me a while to realize I wasnt going mad and that it could be thyroid related. Once I lowered my dose all that negative behavior disappeared and i m back at being the happy person i have always been. I have never had panic attacks or suicidal thoughts in my life.