> Stress increases intestinal permeability and is involved in the pathogeny of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS).

> Vagal nerve stimulation (VNS) can improve intestinal permeability. Targeting the intestinal barrier through VNS opens new therapeutic avenues in IBD and IBS.

From a 2022 article Anti-inflammatory effects of vagal nerve stimulation with a special attention to intestinal barrier dysfunction.
Link: https://onlinelibrary.wiley.com/doi/full/10.1111/nmo.14456#:~:text=The%20vagus%20nerve%20is%20also,irritable%20bowel%20syndrome%20(IBS).