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faiththeillustrious OP t1_j9zt8jt wrote

Reply to comment by Milan__ in The Role of Insulin Signaling in Hippocampal-Related Diseases: A Focus on Alzheimer’s Disease by faiththeillustrious

Yes. Less sugar/artificial sugars/insulin spiking foods = less insulin = greatly lowered risk of insulin resistance = lowered risk of CNS insulin dysfunction and neurodegeneration = lower risk of AD. Insulin resistance causing widespread insulin dysfunction which eventually overrides the CNS's defenses and causes CNS insulin malfunction is what causes AD.

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faiththeillustrious OP t1_j9ztlha wrote

There is a fantastic diagram within the original article of the post depicting how peripheral insulin resistance seen in Type 2 diabetes progressively invades the CNS. (Figure 1)

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roygbivasaur t1_ja21rug wrote

Do you know if there’s been any Alzheimer’s studies with medications that combat insulin resistance like metformin and GLP-1 agonists (semaglutide and tirzepatide)?

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Nyxtia t1_ja2quqq wrote

I remember listening to a talk where apparently metaformin was being studied for anti aging potential since it seemed to reduce a range of diseases that occur with increased age like AD and cancers.

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