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Abstract: >Accumulation of misfolded protein aggregates is a hallmark event in many age-related protein misfolding disorders, including some of the most prevalent and insidious neurodegenerative diseases. Misfolded protein aggregates produce progressive cell damage, organ dysfunction, and clinical changes, which are common also in natural aging. Thus, we hypothesized that aging is associated to the widespread and progressive misfolding and aggregation of many proteins in various tissues. In this study, we analyzed whether proteins misfold, aggregate, and accumulate during normal aging in three different biological systems, namely senescent cells, Caenorhabditis elegans, and mouse tissues collected at different times from youth to old age. Our results show a significant accumulation of misfolded protein aggregates in aged samples as compared to young materials. Indeed, aged samples have between 1.3 and 2.5-fold (depending on the biological system) higher amount of insoluble proteins than young samples. These insoluble proteins exhibit the typical characteristics of disease-associated aggregates, including insolubility in detergents, protease resistance, and staining with amyloid-binding dye as well as accumulation in aggresomes. We identified the main proteins accumulating in the aging brain using proteomic studies. These results show that the aged brain contain large amounts of misfolded and likely non-functional species of many proteins, whose soluble versions participate in cellular pathways that play fundamental roles in preserving basic functions, such as protein quality control, synapsis, and metabolism. Our findings reveal a putative role for protein misfolding and aggregation in aging.

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Well there are things that can help with that first enjoying a protein poor diets makes the body recycle bad proteins and heat therapy is theorised to help the body fold proteins. Also exersize helps the body kill cells that are beyond repair.

Ooof, I guess 3 day fasts are on the menu then.

You could do that, or you could do anywhere from 16:8 to 22:2 most days of the week. I try to do at least 16:8, but it’s 17:7, or even 20:4 depending on the day.

To get autophagy going which is shown to clean up cellular debris you need to fast at least 24hrs. So the normal intermittent stuff which works for blog glucose, etc, isn't long enough for this.

It most likely is if you also work out while on your fast. I go to the gym and/or walk on a slope for an hour while on my fast. Your body burns more than it has.