Darkhorseman81 t1_j98ivtb wrote
Reply to comment by [deleted] in Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression (Feb 2023) by basmwklz
Mega dose is stupid. The body uses what it needs in the moment and excretes the rest.
Slow release Vitamin C, 24 hour slow release, is what you need.
Ancient humans had genes to produce their own constant low supply Vitamin C. These genes were lost or silenced.
This has lead to loss of epigenetic quality control, particularly in blood. As Vitamin C regulates a quality control gene called TET2, which is related to DNMT DNA methyltransferases.
Means we can mutate more and evolve quicker, but makes us more predisposed to cancer, oxidative damage, and dysfunction.
When we were monkeys eating lots of fruit, almost constantly, I guess our body thought it was a good trade-off.
Now with drought flood drought flood levels of Vitamin C in the modern diet, it's lead to epigenetic chaos.
Deficiency in Queuine, unpredictable Vitamin C and Folate levels leads to aberrant oxidation states in Tetrahydrobiopterin, for starters.
Loss of Mitohormensis, as one of a million things this leads to.
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