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SuburbanSquare t1_j96eesu wrote

Reply to comment by johanvondoogiedorf in Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression (Feb 2023) by basmwklz

Vitamin C by IV because eating it, your body maintains a lower dose than was tested by this study

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[deleted] t1_j96qnte wrote

[deleted]

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SuburbanSquare t1_j96r5d6 wrote

Except if you eat a megadose, your intestines only absorb up to “X” blood concentration, and they are dosing 3X or something.

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cobrafountain t1_j96vl5d wrote

You can absorb quite a bit more by taking liposomal vitc, which you can buy or make yourself

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soflasurfr t1_j99hydo wrote

What about vitamin injections. Local doc always trying to sell shot sod vitamin B, etc.

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Darkhorseman81 t1_j98ivtb wrote

Mega dose is stupid. The body uses what it needs in the moment and excretes the rest.

Slow release Vitamin C, 24 hour slow release, is what you need.

Ancient humans had genes to produce their own constant low supply Vitamin C. These genes were lost or silenced.

This has lead to loss of epigenetic quality control, particularly in blood. As Vitamin C regulates a quality control gene called TET2, which is related to DNMT DNA methyltransferases.

Means we can mutate more and evolve quicker, but makes us more predisposed to cancer, oxidative damage, and dysfunction.

When we were monkeys eating lots of fruit, almost constantly, I guess our body thought it was a good trade-off.

Now with drought flood drought flood levels of Vitamin C in the modern diet, it's lead to epigenetic chaos.

Deficiency in Queuine, unpredictable Vitamin C and Folate levels leads to aberrant oxidation states in Tetrahydrobiopterin, for starters.

Loss of Mitohormensis, as one of a million things this leads to.

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[deleted] t1_j96r6ou wrote

To be fair I've never heard of vitamin c overdose, though I've also never looked into the possibility.

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Sheeple3 t1_j97wbeb wrote

Ever eat too many oranges or another fruit? You just get diarrhea, that’s the overdose. https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/expert-answers/vitamin-c/faq-20058030

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finguhpopin t1_j97z185 wrote

One time after soccer I ate like 8 oranges and then puked all over my parents car on the way home

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CharsKimble t1_j98nqn5 wrote

Back in my day we got a 1/4 orange slice at half time and we were happy to get it.

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florbinjerp t1_j97cj73 wrote

It's water soluble so you shouldn't be able to without a lot of help

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MuchFaithInDoge t1_j98324p wrote

Too much Vit C can make you more prone to kidney stones. That's the worst outcome I've heard of

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Grilledcheesedr t1_j989vtn wrote

There always was but the usual corrupt big pharma puppets “disproved” the studies by deliberately using oral vitamin C.

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