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KetosisMD t1_j95rx8w wrote

Reply to comment by crazyhadron in Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression (Feb 2023) by basmwklz

Probably not as thorough as rapamycin.

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Sculptasquad t1_j95v8i1 wrote

"Thorough" always comes at a price.

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KetosisMD t1_j95w9me wrote

Agreed. I’m not saying rapamycin is safe. I’m tempering the comparison of C and rapamycin

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fanghornegghorn t1_j97ij4i wrote

What's wrong with rapamycin?

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erebos290696 t1_j9a0txa wrote

It has several functions which include immunosuppression and fungicide.

The immunosuppressive effects allowed it to be used in organ transplants I believe. And the low rate of cancer in patients using it, lead to the discovery of the mTOR pathway. And it's use in cancer treatment.

I think. Verify everything I've said as it's been a minute since I learned this.

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CrateDane t1_j96s3pv wrote

Well, Rapamycin mainly inhibits mTORC1, while this seems to target RICTOR for degradation and thus preventing assembly of mTORC2. So they would have complementary roles if you wanted inhibition of both complexes.

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