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crazyhadron t1_j95r2zu wrote

Reply to comment by basmwklz in Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression (Feb 2023) by basmwklz

So vitamin C might be a viable and safe alternative to rampamycin for cleaning out your cells, nice.

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KetosisMD t1_j95rx8w wrote

Probably not as thorough as rapamycin.

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Sculptasquad t1_j95v8i1 wrote

"Thorough" always comes at a price.

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KetosisMD t1_j95w9me wrote

Agreed. I’m not saying rapamycin is safe. I’m tempering the comparison of C and rapamycin

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fanghornegghorn t1_j97ij4i wrote

What's wrong with rapamycin?

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erebos290696 t1_j9a0txa wrote

It has several functions which include immunosuppression and fungicide.

The immunosuppressive effects allowed it to be used in organ transplants I believe. And the low rate of cancer in patients using it, lead to the discovery of the mTOR pathway. And it's use in cancer treatment.

I think. Verify everything I've said as it's been a minute since I learned this.

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CrateDane t1_j96s3pv wrote

Well, Rapamycin mainly inhibits mTORC1, while this seems to target RICTOR for degradation and thus preventing assembly of mTORC2. So they would have complementary roles if you wanted inhibition of both complexes.

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[deleted] t1_j96rbdr wrote

What exactly is rampamycin and how does it "clean out you cells" and why do you want that?

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basementreality t1_j97vgw8 wrote

IRC Rapamycin is a drug given to organ transplant recipients that is also used by people trying to extend lifespan. It has been shown in studies to extend the lifespan of pretty much every organism it has been tested on.

It's mechanism of action is too complicated for me to recal but there are lots of explanations online.

It's a super interesting molecule that has a very interesting history as it was discovered next to a statue on Easter Island.

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IAmWeary t1_j98xkw2 wrote

I believe it promotes autophagy and reduces senescence. Probably other things too, but those are big ones.

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A_Dragon t1_j99davh wrote

So if I take liposomal vitamin C it might also extend my lifespan?

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