nickyfrags69 t1_j8x8ysr wrote
Reply to comment by rjmsci in Psychedelics activate the same receptors as serotonin, so why aren't we always tripping? Psychedelics may cause neuronal plasticity and relieve depression by activating intracellular serotonin receptors that serotonin itself cannot, suggests a new study. by rjmsci
>but compounds that primarily modulate the serotonin system do relieve it
That's not necessarily accurate though. First off, Ketamine has a much higher success rate, suggesting at the bare minimum that other mechanisms can relieve depression without touching serotonin receptors. Second, most of the benefit of SSRIs seem to be indirect/downstream, which is why they take so long to kick in.
FUNNY_NAME_ALL_CAPS t1_j90u2b8 wrote
Interestingly enough Ketamine actually does have activity at 5-HT2 receptors.
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