hallgod33 t1_j8x3mjs wrote
Reply to comment by FUNNY_NAME_ALL_CAPS in Psychedelics activate the same receptors as serotonin, so why aren't we always tripping? Psychedelics may cause neuronal plasticity and relieve depression by activating intracellular serotonin receptors that serotonin itself cannot, suggests a new study. by rjmsci
True that, a lot of Shulgin's work will never be peer reviewed so its hard to elucidate which compounds are providing the effects through human models. And the human models are self-reported and all that. But there are non-psychoactive preparations of a bunch of classical psychedelics that provide anti-depressant effects. What makes it non-psychoactive and effective is hard to pinpoint but Shulgin had a lot of raw data available for anyone interested to explore.
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