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TJSnider1984 t1_j8hautx wrote

Uhm, perhaps I've missed something but I'm troubled by the statement "Hydroxychloroquine (HCQ) was used in the screen as a positive control of viral entry inhibition via the spike-ACE2 complex", given that hydroxychloroquine has been proven to be ineffective against Covid, ( https://www.amjmed.com/article/S0002-9343(21)00523-4/fulltext )... How are they asserting that it's a "positive control" aka "some other treatment that is known to produce the expected effect"...

Is this some backhanded way of getting HCQ back on the "effective" list? And if they're using it improperly as a control, doesn't that sadly invalidate the study?

Please understand that I'm actually a believer in and student of Herbal medicine, but sadly know from experience how many false cures and panacea have been promoted.

So, have I missed or misunderstood something?

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GiovanniResta t1_j8hps85 wrote

> https://www.amjmed.com/article/S0002-9343(21)00523-4/fulltext

I'm not an expert, but from reference (4) in the article you cited, it appears that Hydroxychloroquine "is effective in inhibiting SARS-CoV-2 infection in vitro". So it was appropriate for this "in vitro" study.

Unfortunately effective "in vitro" does not always translate in effective "in vivo".

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