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randompersonx t1_j8899t2 wrote

Reply to comment by crazyhadron in Metformin regulates myoblast differentiation through an AMPK-dependent mechanism (Feb 2023) by basmwklz

When you say benefits, do you mean the on-label diabetes treatment, or off label as a diet aid or longevity drug?

I looked into it as a non-diabetic, and the risk of liver damage seemed too high for me to consider it. Sure it makes sense for people who need it, but I’m unconvinced it is always going to enhance longevity… and it certainly isn’t strictly necessary to lose fat.

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crazyhadron t1_j88e6ey wrote

>metformin has also been shown to have beneficial effects on multiple otherdisorders such as cancer, anxiety, polycystic ovary syndrome,cardiovascular and Alzheimer diseases

According to the linked paper in this post.

I've never heard about metformin affecting the liver, only the kidneys through lactic acidosis. I don't have diabetes, and have been on metformin for 4+ years now. Had a full medical checkup 5 months ago, with an exhaustive blood test. Everything was more than optimal, no liver issues either.

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randompersonx t1_j88fauu wrote

Keep track of AST/ALT over time. Part of how Metformin works is it blocks gluconeogenesis which is basically the process of the liver producing glucose. Most likely if you are relatively low body fat % and have hopefully zero (or very low) visceral body fat, this may not matter so much…

But I’d imagine the higher risk comes into play if you have a NAFLD already.

And yes, you are right about kidney issues, too. My dad was on Metformin for a few years and was eventually diagnosed with some mild kidney issues that were believed to be caused by it, and his medications were changed. That said, my dad is overweight and inactive and diabetic… so his case will be very different if you are living a healthy lifestyle.

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DeSquare t1_j8b5y9v wrote

I feel like if using for non diabetic, you can cycle it for longer off terms...seems the older you get the better... probably wouldn't take it unless your diabetes or over 45ish years

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