Submitted by MistWeaver80 t3_10sxm0r in science
Reply to comment by Jumpsuit_boy in New evidence suggests that ‘hybrid’ immunity, the result of both vaccination and a bout of COVID-19, can provide partial protection against reinfection for at least eight months. Immunity acquired by booster vaccination alone seems to fade somewhat faster. by MistWeaver80
Yes, Tdap (tetanus, diphtheria, pertussis) vaccine is good for decades.
Measles, smallpox and HPV vaccines also generate LLPCs and provide protection for a long time.
Tetanus, diphtheria, and pertussis are all bacterial and a couple of the vaccines target the toxin produced by the bacteria and not the bacteria. I asked about viral vaccines.
Measles and HPV are either slow moving or long lasting infections which allow B cells to restart antibodies production over a week of so to stop the infection. They do not need LLPC to be fee effective.
HPV vaccination induces memory B cells^(1) and there are sustained serum antibodies that suggest LLPCs are also vaccine induced^(2)
I stand corrected. Thank you. The non correlation between B cells and circulating neutralizing antibodies is interesting and given what you are studying pretty exciting. The second paper probably quashes my theory that the sustained circulation was due to exposure since it seems to maintain a constant level after two years. Two questions if you have time. Is this a similar reason for the smallpox vaccination lasting as long as it does? A lot of the vaccines for bacterial infections target the toxins produced by the bacteria so I have mentally separated vaccines for virus snd bacteria into two columns about how long they are effective. Given what you have pointed out just how terrible of a general rule is this?
Once again thank you got taking the time to point out that I was wrong. I do appreciate it.
There hasn't been a ton of recent testing of the smallpox vaccine. We don't have smallpox challenge trials for example.
Smallpox immunity wanes after vaccination, but still can prevent infection and severe infection.
https://www.health.ny.gov/publications/7022/
Part of what makes the smallpox vaccine effective, is that smallpox is not circulating in the population and mutating. Smallpox is also a DNA virus, and DNA viruses tend to have fewer mutations, so vaccines continue to work for them, rather than the flu which is RNA and mutates like crazy. It's probably most effective to think about the antigen that the vaccine is training your body to target, and the delivery mechanism for that.
mRNA vaccines are really going to change the vaccine landscape.
Smallpox isn’t that long. I think it is 5-10 years.
Viewing a single comment thread. View all comments