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Dandan0005 t1_iybnwih wrote

Reply to comment by NPVT in Alzheimer's drug lecanemab hailed as momentous breakthrough by Methoszs

Alzheimer’s is already a death sentence.

And honestly, having see people go through it, some would argue it’s worse than a death sentence.

They estimate 19 more months of independent life with this.

Is it a miracle? No. But it’s hardly nothing.

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moo100times t1_iycv2a8 wrote

It's not just death or improvement, it is all the middle ground of increased disability and impairment that it can cause (including swelling and bleeding) can likely leave a person much more disabled and impaired, whilst still alive, than Alzheimer's would itself. That the phase 3 study did not reveal any but already two in an open label, extension study is itself highly concerning, and in my opinion shows this drug is clearly not near being ready for market.

Alzheimer's is bad, but showing at best a modest improvement on oddly chosen end points in early disease whilst risking significantly disabling side effects that works directly against what you hope the drug will achieve makes me concerned.

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