It'll be a bit of a drive but the Delaware Water Gap's Dingman's Creek Trail, George W. Childs Park Trail (currently closed for construction), the Pocono's Environmental Education Center's sensory trail, and part of the McDade Recreational Trail are accessible.

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Edit: The Dingmans Creek Trail says on the website specifically that it is accessible for wheelchair users.

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There's also The Trail for Everyone which is ADA accessible.