Take a look at 65 Dwight Street which is managed by Chelsea Company

I lived at this property and their 80 Howe property in law school and they’re a solid/responsive landlord.

Apart from being more than a little ugly on the outside, 65 Dwight might check some good boxes for you. It is close to the hospital and has its own off-street parking spaces or individual garage spaces.

Really the only issue I ever dealt with was some of the noise pollution from ambulances en route to the hospital, but it was not particularly disruptive.

Edit: their George St property may be a little nicer (don’t have personal experience with it) and is in the same neighborhood.

As to your original question, High Street is possibly one of the loudest areas of downtown due to the frat house.