Simpsons hasn‘t been funny in like a dozen seasons but it used to be good satire of life in the US. Family guy is mostly simple humor or absurd stuff for sure but also some great satire, for example I love how the chicken fights ridicule action movies, it was so over the top and came out of nowhere, really cracked me up. Southpark would have never been included in your list if the quality of the show didn‘t drop massively. Rick and Morty is just garbage imo, I can see the appeal but just like Futurama the setting and everything about the show just seems highly irrelevant.