I don't know where you are in Massachusetts, but Second Glance in Gloucester is a thrift shop operated by The Open Door, our local food pantry. All the revenue from the second-hand items sold there fund the work of the pantry, and Second Glance also provides non-food household items to individuals and families in need. I can't speak highly enough of the team of The Open Door and Second Glance for all the great work they do in the communities they serve.

I know they go out and pick up donations sometimes, but I think it is going to depend on how much you've got and where you are. If you aren't around our area, there may be something similar near you. Still on the North Shore, but I know that Beverly has thrift store that follows a similar model. I'd go with any of these in order to support your community/communities near you over some of the big names.