The pressure from the noise cancelling in my Sony WH-1000XM3's can sometimes aggravate a headache.

I have found that, depending on what I am doing, I will use either the ANC headphones or IEMs with foam tips for passive, or Emu-Teaks, which are Semi-Open and very comfortable for me.

I recently picked up some Air Pods Pro 2s and haven't had the same issue with their ANC implementation as I did with the Sony's.