Before the pandemic I worked for an organization that did queer nightlife events in Boston. I haven't been going out as much since I shacked up (and covid) but your best bets are going to be sapphicnights or lesbiannightlife events. Queeraoke at Midway in JP has always been popular with queer women but it's on Thursday nights. Someone else mentioned DeLux which I haven't actually been to but now I'm curious about that one.

Club Cafe caters strongly to cis gay men so if you're looking for other women, that'll be tricky. Still fun to go dance though, and I feel like with so many other spaces closing it might be a more mixed crowd than it used to be.

Outside of nightlife, you'll see the most queer women in JP, and also Davis Square and Union Square.

It's a rite of passage to go to "baby dyke weekend" in P-Town, which is Memorial Day weekend. Definitely find some friends and check that out. If you're looking for a hookup, you'll find it haha. If you don't go to that, Zolita and Fletcher are both performing at Boston Calling this year so that'll draw a sapphic crowd too. There's also Women's Week (also P-Town) in October. Farther out, Providence RI, Ogunquit ME, and Portland ME are also popular weekend trips for queer women in the area.

Personally, I love Salem (MA). Not really for nightlife, but queer energy is definitely dominant there. I feel like a ton of the queer women and trans people in Boston end up leaving for Salem once they hit 30.