It depends what you are looking for in a hotel. The Pendry is a swanky property and smack in the middle of Fells Point but quiet when you’re inside. It was the former police station featured in the tv series Homicide. The Hilton Harbor Point is where CindyLou’s Fish house is located. Its also called the Canopy Hotel and has free bikes to explore the area. It’s a newer hotel overlooking the water and well located in Harbor East toward Fells Point. The restaurant and bar are nice.
Bygone at Four Seasons is a rooftop bar in Harbor East. Henderson Wharf is very nice and quiet but still well located in Fells Point.

The other option is staying in Harbor East and walking into Fells Point. Both are nice areas. Harbor East may be preferable but both areas are nice. Harbor East hotels to consider are the Marriott Waterfront and Four Seasons.
A good property that’s well priced is the Courtyard by Marriott but no bar.

Consider the Elk Room for a great bar