There's not a ton of options. Water Street has Water Street Grill and Peter's Pour House, both good neighborhood type spots. There's Supano's next to them for an old-school vibe. Further away you have Pratt Street Ale House or Mick O'Sheas. Otherwise you have the hotel bars, the B&O would be the best and is a decent spot. I don't know that anything is open late night anymore though, Mick O'sheas is probably the best shot for that- defintely check hours. Werners and David and Dads also have bars but close early, I think 8PM for both.