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bynarie OP t1_j6dubgg wrote

Reply to comment by aziridine86 in Can you (roughly) determine the dosage of a drug taken based off of the blood concentration? by bynarie

Thank you. Yea, and there were also other drugs in the system, specifically diphenhydramine and cyclobenzaprine. I know there's just no way to figure it out. But 100mg of hydrocodone doesnt seem like a lethal dose for a person with tolerance.

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Wyvernz t1_j6dxant wrote

Sedating drugs can work synergistically as well, so while 100 mg probably wouldn’t be lethal in someone with significant tolerance if you add other sedating meds like diphenhydramine and cyclobenzaprine the overall level of sedation may push them over the edge.

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preownedliver t1_j6dw8pw wrote

Each person is different, but I happen to know that for a healthy 6’5”, 200lb 27yr old male, who was a moderate opiate addict, a dose of 25 10mg pills (250 mg hydrocodone) taken orally of hydrocodone did not cause overdose. Their were ill effects, but no loss of consciousness and no hospitalization. Again, each person’s chemistry is going to be different, but that did happen.

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Scarlet- t1_j6e89lg wrote

What’s the age of the person?

100mg is a bit high. Even for someone with tolerance. I personally have never seen a prescription for Norco 10-325 to be taken 10 pills at a time.

But two major concerns present itself:

  1. Respiratory depression induced by opioids
  2. Liver damage caused by the acetaminophen in the Norco; assuming you are from the US where just getting hydrocodone by itself is not really a thing, minus special cases.
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SagginDragon t1_j6dxq51 wrote

Pretty sure opiate levels continue going down in the blood for a while after death

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