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bynarie OP t1_j6dtny4 wrote

Reply to comment by TRJF in Can you (roughly) determine the dosage of a drug taken based off of the blood concentration? by bynarie

Very good explanation. Thank you.

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[deleted] t1_j6eg5ia wrote

[removed]

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teratogenic17 t1_j6ejw4s wrote

I'd like to see some doctors turn from a punitive and sometimes deadly approach with Vicodin.

I have chronic nerve damage pain, and I had to pressure my otherwise sympathetic doctor, to remove the acetaminophen from my daily dosage.

If they had not done that, I would surely have died by now of liver and kidney failure, over the past decade.

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chocokittynyaa t1_j6ejjnm wrote

Kidney/liver issues definitely, but also genetics can affect drug distribution and elimination for many medications (for example, loss or gain of function mutations in drug transporters).

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