volyund t1_j5118c4 wrote
Reply to comment by Silverjeyjey44 in Is there any difference in efficacy when a vaccine is administered somewhere other than the upper arm (e.g. on the foot)? by MercurioLeCher
Because you don't want something immunogenic circulating in your bloodstream. That's how you get cytokine release syndrome, shock, and dead patients. You want localized immune reaction somewhere safe (like an arm), where immune cells can be recruited to from blood , tissue, or lymph; to do their thing.
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