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Alittlebitmorbid t1_j4varmd wrote

I think this has to do with several factors. I will use cholesterol as an example.

Factor A: testing methods change over time, I doubt the methods of 1930 were the same or as exact as they are today

Factor B: research of acceptable factors, cholesterol for example is usually divided into two sorts, and for years it was state of the art too high cholesterol of any sort is bad, then it changed to one sort being the "good" cholesterol, so higher levels should be tolerated of this kind and lower of the other kind

Factor C: this may surprise, but... pharma industry, they profit from lower tolerance as there is a huuuuge market for statins (I could name half a dozen statins right now), so they commission studies which show the wanted results and many people do not know how to look at the studies and results properly

Factor D: actual change in eating habits, genes, environment, etc.

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ScienceIsSexy420 t1_j4w5jm3 wrote

You're point about testing methods is a great one, and I was going to make that point myself. I work as a chemist refining the next generation of testing methods, and when we use a new method we need to do large numbers of cohort studies, to document the normal ranges with the new methodology. A new methodology may make the averages go down, and it doesn't mean that everyone magically got healthier, it just means this new test is different.

I do have to be my naturally pedantic self and point out that there are not two kind of cholesterol. What you are referring to are actually called lipoproteins, for the life of my I don't know why we call them cholesterol but it's of course not just you. Cholesterol levels are an entirely different test, and there is only a single kind of cholesterol, called cholesterol. Lipoproteins are responsible for collecting, depositing, and moving around all of your lipids (triacylglycerides and cholesterol) throughout your body. HDL lipoprotein tend to play a role in the deposition of fats, especially arterial cholesterol, (which is why we call them "bad") while LDL lipoproteins tend to help to remove such deposits (why they are the "good" cholesterol). Importantly though, neither is actually a kind of cholesterol, of which there is only one (okay one natural cholesterol, I actually used to work in a synthesis lab where we specialized in making unusual forms of cholesterol).

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Alittlebitmorbid t1_j4x8tzt wrote

Thank you for clarifying that, I did not know (and I'm a nurse)!

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ScienceIsSexy420 t1_j4xzdyz wrote

My pleasure! As an added bonus that you didn't ask for at all, did you know that consumption of dietary cholesterol, and elevated endogenous cholesterol levels, are not well correlated? We don't really know what causes elevated cholesterol levels, but there's not much evidence that suggests that diet is a large contributing factor. Conversely, consumption of excess lipids can cause hyperlipidea.

Also, I labeled the good and bad cholesterol incorrectly in my previous comment, but I fixed it now. LDL=bad, HDL=good

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