Submitted by heartless-tramp t3_10cfqkv in askscience
Would the Organism change? We only changed the order of the DNA that coded for one single protein so all the proteins are the same
Submitted by heartless-tramp t3_10cfqkv in askscience
Would the Organism change? We only changed the order of the DNA that coded for one single protein so all the proteins are the same
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Yes but the result would be a little boring. It would without doubt create a nonviable organism.
The reason is that DNA contains critical regions outside of the protein coding part. These include promoters, repressors, enhancers, and numerous RNA transcripts that serve a wide array of functions. Divorcing the part of the DNA that codes for a protein from all the other parts that regulate the expression of that gene would result in dysregulated expression and would certainly be lethal if applied to all genes simultaneously.
For the longest time we didn't know what the purpose of the DNA between genes served. More recently, we have been discovering rhat these non-ncoding sections play important regulatory roles by providing binding sites for promoters, repressers, histones, and other proteins that interact with DNA. For a particular gene to function properly, it not only needs the nucleotide sequence to remain intact, but also for its regulatory functionality to remain the same. Altering the non-coding DNA surrounding a gene will almost certainly change its level of transcription.
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Thank you so much! I understood it now. (but i am pretty sure if i tried to research more into the topic, i wouldn't understand so much...lol) Regardless, I enjoy learning about biology (I actually participated in a biology competition a couple days back and lost xx)
happy to help. The question you're asking here concerns a massive chunk of biology so theres a tremendous amount to learn. If you want to learn more, the key is to take it in bite sized chunks and go at your own pace. To start, you could look at a simple case and search "explanation of the lac operon" which was one of the first systems in which gene regulation was well studied, or you could just search the term "gene regulation". Alternatively any biology textbook will have tons of information on gene regulation, even the slightly out of date ones. Finally you can check out the book "Endless Forms Most Beautiful" for a slightly lighter read, written by an expert in the field and a great science communicator. This last option might be the most enjoyable because of the digestible writing style compared to a textbook.
omg thankss sm
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i'm confused, was your question about changing the dna sequence of just one protein, leaving all the rest of the dna unchanged? that's how i interpreted it. but askoemnzviwcasf seems to have interpreted the question as you changed all parts of dna that code for a protein. was their interpretation correct?
Endless Forms Most Beautiful is an incredible read and I will never stop recommending that people pick it up.
changed the locations of all dna that code for a protein
yes it was correct
[deleted] t1_j4fvw52 wrote
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