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DukeSuperior_Truth t1_j4izbf2 wrote

Reply to comment by catiecat25 in How do the new generation of weight loss drugs (Semaglutide, tirzepatide) work and why are they seemingly so effective? by harpoonhambone

Fellow physician here. Why does it have to be paired with exercise/certain diet? It doesn’t work on your metabolism without exercise?

That sounds to me like the old stigma is still going strong. Unless you mean the wink-wink kind of lifestyle mod we do for cholesterol or hypertension…it is certainly nice if folks exercise and eat plants, but the drug either works and is safe and we use it to treat a medical condition…or its doesn’t. Patients shouldn’t have to adhere to a certain program to be given necessary medication.

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PsychoticGiggle t1_j4jdokz wrote

It definitely works without lifestyle modification, because it still reduces appetite. But all the research has been done on patients that they also promoted lifestyle modification to. And ultimately if someone stops taking the medication hopefully it has helped with lifestyle changes to reduce the amount of weight regained.

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