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Alwayssunnyinarizona t1_j37ci4a wrote

With hepatitis specifically, there is damage to the liver. This causes pain, which can trigger nausea as mentioned, but the liver is responsible for processing various components of the food you're eating (and things like antibiotics or other drugs you might be injected with during an illness). If the liver can't do its job well enough, those components are left unprocessed, which can trigger sensations of nausea in the brain.

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seeriktus t1_j38d4cu wrote

Satiety and hunger are controlled by hormonal circuits. If something interferes with the ability to release those hormones, or the bodies ability to respond to those hormones, then they will be impacted. See circuits for Ghrelin, Leptin. For example if an autoimmune disease targets cells holding ghrelin receptors in the hypothalamus then you might get anorexia (as well as brain damage).

A major thing that goes on during viral infections is the bodies release of interferon, which has the side effect of reducing hunger. https://pubmed.ncbi.nlm.nih.gov/?term=interferon+hunger&filter=pubt.review

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