Nitz93 t1_iyeec6r wrote
Reply to comment by DudoVene in What does it mean when someone says an artificial sweetener 'spikes insulin'? Also, if you're consuming a bunch of carbs along with it, is that such a bad thing? by Frangiblepani
The problem is that such thinking comes from theory and theory always has to make way for reality.
2020 a study was published that showed that in type 2 diabetics the ones who reported to using sweetener all had a higher fasting glucose : insulin ratio.
Now if you check the data then most of the type 2 diabetic people without artificial sugar cosumption had a ratio of below 4.5 (which is the cutoff for insulin resistance [weird data for diabetics but maybe their meds are working]) and all below 10.
While the other group hmwas generally higher and many above 10.
So either that data is super convincing or faked, for the sugar lobby this wouldn't be the first time.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014832/
Besides the glucose dependent insulin response of the pancreas there are other Pathways too. Many hormones modulate the response.
Bottom line is I guess if you take normal people who consume lots of fake sugar and check their insulin resistance they will show no signs of it. Maybe ask your doc at the next check up to do insulin too and check the ratio. Or check your hunger levels and see how you respond.
Anyways I consumed tons of it and sugar doesn't taste good anymore so I take that as a triple win. If I had a slightly worse (not near pathological) level of insulin resistance in that time then I was totally right not caring about fake sugar consumption.
Also insulin is misunderstood. People look at t1 diabetics and what happens of they use too much insulin to make conclusions about that hormone, this of course is the wrong approach. If you eat and insulin puts glucose into your cells you will be satiated. Usually this correlates with the amount of insulin.
The hunger problem after an insulin spike comes from the sugar (sugar like sugar not blood glucose) blocking leptin signaling in the brain.
DudoVene t1_iyefv8y wrote
thanks for your comment. I took a look on the study you quote but only AFTER answering here.
I have in mind (and no evidence or precise mechanism) sweetener may cheat the brain (hypothalamus ?) while eating, leading to a release of glucose in blood. that will lead to insulin spike but indirectly induced by sweetener itself.
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