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morebass t1_iw3era2 wrote

Reply to comment by RazedByTV in Do all steroid hormones increase blood glucose and cause diabetes? by [deleted]

Do you mean a SERM? An aromatase inhibitor will effectively lower the body's estrogen by preventing androgens from being converted to estrogen via the aromatase enzyme. A SARM binds to and activates specific androgen receptors, to mimic the positive effects of something like testosterone, without the negatives (in theory but not in practice)

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RazedByTV t1_iw42obg wrote

No, but somewhat similar end result if you use a SERM like enclomiphene (with one exception of estradiol levels being different). An aromatase inhibitor will cause testosterone levels to rise, and an excessive amount of inhibitor will tank estrogen levels if aromatase is inhibited too much. So it sounds like ideally, the SARM would avoid the negatives associated with increasing endogenous testosterone.

Edit for clarity: Lowering the (male) body's estrogen causes production of more testosterone, as the body uses estrogen level to determine how much testosterone to produce. Reduce conversion of testosterone using aromatase inhibitor, body has lower estrogen, and makes more testosterone. Trick body into thinking there is less estrogen using SERM, body makes more testosterone, and you end up with somewhat elevated estrogen.

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morebass t1_iw4akmu wrote

I see, to answer your previous question, a SARM will decrease your body's ability to produce testosterone on its own as well as having the deleterious effects of high androgen levels, and since it is metabolized by the liver, effect hepatic function...

An AI lowers circulating estrogen which may boost "natural" testosterone (causing the same effects from higher androgen levels) as well as the negative effects of aromatase inhibitors in general (vision and hepatic involvement). Estrogen also serves to counteract some problems caused by high androgens, so lowering estrogen in order to increase testosterone may negatively effect blood pressure, cholesterol, lipids, joint health, electrolyte balance.

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