heteromer t1_ivsrbz2 wrote
Reply to comment by Optimal-Conclusion in How do medicines like Aspercreme work to relieve nerve or muscle pain if they are topical and not transdermal? by freakydeku
The epidermis is highly keratinised to prevent systemic absorption. Drugs that absorb systemically in concentrations high enough to exert an effect are quite rare, and the epidermis does quite a good job as a barrier.
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