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xiledone t1_ivo3jix wrote

Reply to comment by Saint_Oliver in How do medicines like Aspercreme work to relieve nerve or muscle pain if they are topical and not transdermal? by freakydeku

Both, but heavily depends on the molecule and the cell. The question is more nuanced, so unfortunately so is the answer, cuz the body is so complex there's rarely a straightfoward answer.

But if allowed to overgeneralize, most of it goes inbetween and "through" the wall that the cells make.

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