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dijc89 t1_ixlywqm wrote

Prions are not microorganisms. They are proteins, which can misfold and thereby lead to prion-diseases.

Therein lies the problem of curing these diseases. There is no easy way of destroying proteins in the body, much less so if they are not inherently foreign to the immune system.

This might be of interest: https://www.thelancet.com/article/S1474-4422(22)00082-5/fulltext

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[deleted] t1_ixm2wfv wrote

[removed]

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CygnusX-1-2112b t1_ixm3rlr wrote

Big oof leading with the microorganism thing. Prions are not microorganisms at all, nothing's alive in there.

You're at the absolute baseline of information here it seems, so to get the information you're looking for just get on YouTube, type "What is a Prion", click the first video you see, and get learned.

Just saw you're a Polska, understand the accidental use of an inaccurate word now. My advice still stands, though. Check YouTube.

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Aviyara t1_ixm8wt1 wrote

Imagine you were a sword-smith in Ye Olden Days. Your smithy makes excellent swords: straight, solid bars of steel with sharp edges, nothing special or odd about them.

One day, one of your apprentices brings in a new hammer he got from a sorceror on the edge of town. He takes a hot bar of steel from the forge and gives it a whack with the hammer.

The bar, which was this shape: |

transforms into this shape: ›

...and immediately becomes powerfully magnetic.

That magnetism wrenches it free of your apprentice's hand, and the bent bar of steel flies off through the air towards the sword in your hand.

They collide: ›|

and the impact, plus the magnetism, bends your sword to match: »

Your bent sword now also becomes powerfully magnetic. They both are drawn off into your shop, where you have many swords hanging on racks and shelves.

Chaos ensues.

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Prions are no more alive than steel or water are alive. They are proteins, twisted by luck into a terrible shape. It is their shape that makes them dangerous; that shape - like the magnet-swords above - bends any identical sibling-proteins they collide with, twisting them into that same cursed shape. And much like a sword bent into a magnetic wedge, they are also useless for their original purpose.

This is also why there is no cure: there is no living thing involved. Antibiotics are poisons tailored to kill bacteria - but prions don't eat. Antivirals keep viruses from entering a cell or block them from using cell machinery - but there's no cell involved here. This isn't a biology process - this is a physics process.

It would be like trying to make a drug that stops lava from melting rocks.

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kirsiuu OP t1_ixmfyic wrote

Great metaphor! Now i get it. Thanks!

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