bio_med_guy t1_is4zg4j wrote on October 13, 2022 at 10:33 AM

Your question can be taken from several prospective, are you talking about second hand/passive effect of smoking on children? Are you talking about effect of smoking while pregnant or breast feeding? Or are you talking about transgenration inheritance?

Will assume you are talking about transgenration inheritance since you mention epigenetic. We actually have very few data, from what we have on paternal contributions to the offspring’s health, is that paternal exposures to smoking of cigarettes prepuberty to be associated with increased risk of asthma and reduced lung function as well as of increased fat mass in the offsprin.

https://www.nature.com/articles/s41598-021-04504-0

https://academic.oup.com/biolreprod/article/105/3/667/6355554

The authors in the second study do suggest epigenetic mechanism involved through small sperm RNA. Is that what you are referring to??

riztikhein OP t1_is9rxy5 wrote on October 14, 2022 at 10:22 AM

Thanks for the reply! I’m referring to all that, actually. I’m interested in how and why are the respiratory and immune system of smokers’ offspring different, eg if the offspring have more risk of respiratory infections or asthma, then why and how does it happen, whether is it irreversible, like do the oncogenic substances do something to the lung tissue itself to weaken the immune response there etc. Seems like a complex interesting topic and I am just curious. :D