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screen317 t1_ir8ri2z wrote

Reply to comment by longshot_MD in Can t-cells turn into cancer? Are they any more or less likely to do so than any other cell? by iBluefoot

> Abnormal T-cell malignancies, therefore, most commonly present as a hematologic malignancy which is to say the problem is in one of the early stage cells in the bone marrow

This is not accurate. ETPs (T cell precursors) don't have their Rag genes active and wont be susceptible to T-ALL. So, there aren't really any BM-derived T cell malignancies. It's primarily Pre-T ALL that originates in the thymus, since those are the cells actively rearranging DNA.

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