Physical tolerance is different from mental tolerance, genius.

Physical tolerance is like if you get drunk enough, it takes more to get you drunk. Like the same level of drunkness literally gets physically harder because your body gets better at breaking down the poison.

Mental tolerance is like you get the same level of drunk but get bored of it. Like the pain relief is the same amount, you just want more now. Like you want total pain relief, which simply isn't possible unless you're completely healthy to begin with.