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danby t1_jbz36wk wrote

Reply to comment by slashdave in What exactly is going on when a protein (or other molecule) binds with a receptor? by Eat-A-Torus

> The intermediate states are irrelevant

Irrelevant to what? They seem pretty relevant if we're studying protein dynamics.

> It is only the free-energy difference of the two states (bound and unbound) that matter.

It's the only information that matters to what? If we're studying protein dynamics can you predict if a protein undergoes a change in structure form the change in free energy alone?

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