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babar90 t1_j9z6no7 wrote

H1N1 1918 was pretty severe and deadly in population lacking immunity. Yeah not much reason to assume that a H5N1 epidemic should be worse and that making a vaccine should be more difficult. Efficacy of H1N1 vaccines are hindered by the fact that we are all already immunized. In naive mice H1N1 and H5N1 are comparable.

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nicuramar t1_ja12sy0 wrote

What about in skeptical mice? Or alternatively, what does naive mean in this context? :)

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RunObjective1970 t1_ja2bcrb wrote

hah. it means their bodies have no antibodies, have never seen a virus like that before.

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