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eckart t1_j8m4dx2 wrote

Reply to comment by echolaliac in Why do dopamine reuptake inhibitors not treat Parkinson's disease? by unripenedboyparts

Wouldn’t that imply that a significant amount of recreational stimulants such as cocaine or many cathinones (‘bath salts’) help prevent parkinson?

What about dopamine release agents such as amphetamine/methamphetamine?

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echolaliac t1_j8nbr5l wrote

Cocaine probably, I don’t know about cathinones, but dopamine release agents do the opposite because they displace dopamine from synaptic vesicles into the cytoplasm, which is why too much meth actually kills dopamine neurons. A DRI like cocaine or methylphenidate have been shown to prevent this kind of neurotoxicity.

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