Submitted by Few_Abrocoma1475 t3_11cehnu in askscience
d0uble_h3lix t1_ja2v8xo wrote
Yes. Any two simultaneous double-stranded breaks have the potential to be stitched together during repair, although translocation events are going to be much much less frequent than the correct recombination (and observed even less frequently than that due to spontaneous death or targeted removal of cells where this occurs). But it is not impossible for the cell to survive and even propagate after such an event.
Here’s a paper discussing the topic: https://www.pnas.org/doi/10.1073/pnas.1410112111
Few_Abrocoma1475 OP t1_ja33iw1 wrote
Thanks this was super interesting to read more about
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