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good thing here (probably) as we need help with this. it's a plague.

now if only they could get docs to stop prescribing medications that are known to cause brain damage and or dementia (statins, lyrica, neurontin, etc).

Is this anything like the last one, which is wildly expensive and no insurance company will cover it because it wasn't proven to be effective?

Read the article:

>It has shown “potential” as an Alzheimer’s disease treatment by appearing to slow progression, according to Phase 3 trial results, but it has raised safety concerns due to its association with certain serious adverse events, including brain swelling and bleeding.

>If (continued) trials confirm that the drug provides a clinical benefit, the FDA could grant traditional approval. But if the confirmatory trial does not show benefit, the FDA has the regulatory procedures that could lead to taking the drug off the market.

Sounds like it just showed potential for removing amyloid plaques, which are still not firmly shown to be the primary cause of the cognitive decline.

About 14% serious adverse effect rate vs 11% in placebo. The brain issues had notably higher frequency

>in people who had a gene called APOE4, which can raise the risk of Alzheimer’s disease or other dementias.

Which stinks (and is poorly written. The gene is APOE and APOE4 is just one variety of APOE).

Statins?

Alzheimer's is a frightening thought. Crazy to think how your memories and brain deceive you. This is great news.

The plaques are not the problem - been proven for 20 years that you can remove all the soluble and insoluble beta amyloid and there is no clinical benefit but because beta amyloid chains integrate into blood vessels, there is cranial hemorrhaging. This mAb is no different and should not have been approved, IMO.

Yeah going to need to see some evidence on this one.

Any risk of statins is far outweighed by the benefit they provide. And I haven't seen anything confirming the risk proposed by that commenter.

I had a friend who was tirelessly working on Alzheimer's. She slept in her lab and barely ever left. She had received a large sum of money to further her research, but the pressure was too much. Unfortunately she lost her life due to deep sadness a couple of years ago. This news brings me joy because I hope it would bring her some too.

Nope

It truly is.