Breakthrough is quite the exaggeration.

Saying that we should focus more on dopamine signaling regulation than dopamine signaling, can be analogized to the importance of analyzing how traffic is controlled instead of the traffic itself.

Another statement they make can be summed up to say that they know effective treatments are effective:

"Substance use disorders and mental disorders often co-occur, and we know that the most effective treatments help people address both issues at the same time."

This study found exactly what others have before it, and they also identified additional genetic markers. There is no breakthrough in treatment, the findings only identify potential areas for more research to happen to hopefully find other treatments. The results are significant, so it's frustrating that the article is click baiting and exaggerated.