I'm really not familiar enough with the subject to say for sure. The factors you have to look at are effectiveness, environmental persistence, solubility, and side effects.

If the organic solution is only 75% effective, you run the risk of ending up with resistance over time. If the organic solution contains chemicals that persist for months or years that is also bad. One of the good things about roundup (afaik) is that it breaks down quickly after application. Where and when the solution is applied matters as well. If the site is on a hill or near a watershed the chemical needs to be safe for aquatic life. If it is something that affects pollinators, you don't want to apply it while the plant is in bloom.

If you want some better information, check out https://youtu.be/ZgsBzEelZJY . He tests a bunch of different methods and gives an overview of what was effective.