As great as it sounds, it's pretty much impossible. A lot of chemicals are moved by ship/barge, so being along the river is pretty much a must. If you introduce pipelines or more trucking, that's just more risk for spills. On top of that, moving them would be prohibitively expensive and would probably result in a relatively unspoiled area getting destroyed to place the new location. The better way is to a) reduce they need for whatever chemicals and along with that better regulate their handling and enforcement to go with that.