Personally I really like the layout.

I use my keyboard for competitive gaming and work. Having navigational switches like Home and Insert is nice, but the problem is since I'm right-handed, and the nav cluster is on the right side, my mouse hand will sometimes hit against my keyboard when I'm quickly turning in FPS games.

I've more or less solved it by angling my keyboard so the left side is closer to the monitor than the right side, but having my nav cluster/keypad on the left side would also solve that issue.

All in all, I think it's a great setup, and I wish OEM's like Steelseries offered that layout.